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CALGB – 50 Years of Cancer Research

September, 2006

The Cancer and Leukemia Group B (CALGB) is a national clinical research group sponsored by the National Cancer Institute, headquartered at the University of Chicago with its Statistical Center located at Duke University. The CALGB was founded in 1956 with a goal of bringing together clinical oncologists and laboratory investigators to develop better treatments for cancer. Since 1956, CALGB has grown into a national network of 29 university medical centers and over 225 community hospitals with more than 3000 oncology specialists who collaborate in clinical research studies aimed at reducing the morbidity and mortality from cancer, relating the biological characteristics of cancer to clinical outcomes and developing new strategies for the early detection and prevention of cancer.

CR&T is proud of the affiliation of our Medical Director, Dr. Richard Silver, and Medical Advisory Board members Dr. Scott Wadler, Dr. Linda Vahdat, Dr. Morton Coleman, Dr. Anne Moore and Dr. Mark Pasmantier with CALGB since its creation. All have played active leadership roles over the years in the research that has been accomplished. Dr. Silver and Dr. Wadler have served as principle investigators for the region in past. Dr. John Leonard, Professor of Medicine at Weill Cornell Medical College serves in that post currently. Dr. Silver also served as Acting Chair and Vice Chair for the national organization.

CALGB research is focused on seven major disease areas: leukemia, lymphoma, breast cancer, lung cancer, gastrointestinal malignancies, genito-urinary malignancies, and melanoma. In each of these areas, multi-modality treatment programs are designed by national experts in an attempt to cure more patients with cancer. Treatment protocols are carefully developed and monitored and are often coupled with studies of cancer biology, quality of life, pharmacology and cost-effectiveness measures so that improvements in therapy can be placed in the proper clinical perspective in today's health care marketplace. The CALGB pays particular attention to the rights of cancer patients participating in clinical research studies by working with the Department of Health and Human Services' Office for Human Research Protection (OHRP).

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